Zovirax (Acyclovir)

Zovirax Review

Zovirax Cream is indicated for the treatment of Herpes Simplex virus infections of the skin including initial and recurrent genital herpes and herpes labialis.

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Zovirax Drug Class and Mechanism

Acyclovir is a synthetic purine nucleoside analogue with in vitro and in vivo inhibitory activity against herpes simplex virus types 1 (HSV-1), 2 (HSV-2), and varicella-zoster virus (VZV). The inhibitory activity of acyclovir is highly selective due to its affinity for the enzyme thymidine kinase (TK) encoded by HSV and VZV. This viral enzyme converts acyclovir into acyclovir monophosphate, a nucleotide analogue. The monophosphate is further converted into diphosphate by cellular guanylate kinase and into triphosphate by a number of cellular enzymes. In vitro, acyclovir triphosphate stops replication of herpes viral DNA. This is accomplished in 3 ways: 1) competitive inhibition of viral DNA polymerase, 2) incorporation into and termination of the growing viral DNA chain, and 3) inactivation of the viral DNA polymerase. The greater antiviral activity of acyclovir against HSV compared to VZV is due to its more efficient phosphorylation by the viral TK.

Zovirax Uses

Aciclovir or acyclovir (USAN, former BAN), chemical name acycloguanosine, is a guanine analogue antiviral drug, marketed under trade names such as Zovirax and Zovir . One of the most commonly-used antiviral drugs, it is primarily used for the treatment of herpes simplex virus infections, as well as in the treatment of herpes zoster.

Zovirax Side Effects

Although side effects from Zovirax are not common, they can occur. Tell your doctor if any of these symptoms are severe or do not go away: burning, stinging, itching, or rash when ointment is applied headache upset stomach vomiting diarrhea or loose stools If you experience any of the following symptoms, call your doctor immediately: severe rash severe itching fever confusion yellowness of the skin or eyes blood in the urine stomach pain

Zovirax Pregnancy

Zovirax Overdose

An overdose of this medication is not likely to occur. If you suspect an overdose or ingestion of Zovirax topical, call an emergency room or poison control left for advice.

Zovirax More Information

Zovirax Cream is contra-indicated in patients known to be hypersensitive to acyclovir or propylene glycol. Zovirax is most effective if it is started within 48 hours of when the rash first appears. Follow the directions for using Zovirax provided by your doctor.